Journal of Okayama Medical Association
Published by Okayama Medical Association

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癌と血液肥満細胞について 第2編 癌毒素による血液肥満細胞の動態及びその意義について

梶谷 清己 岡山大学医学部第2外科教室
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抄録
A). Fluctuation of mast cells in blood was investigated following injection of ten per cent of cancer extract in rabbit, and results obtained were as follows. Mast cells were markedly increased after injection of cancer extract, but not after injection of gastric mucosa in peptic ulcer as control. It was, namely, concluded experimentally that the mast cells were increased by the so-called cancer toxin in the extract. B). Fluctuation of mast cells in blood was investigated following injection of Guronsan (glucuronic acid), Moriamin-S (amino-acid) or Tespamin (TSPA) in rabbit, and results obtained were as follows. 1). Mast cells were increased with injection of Guronsan, but decreased after cessation of the injection; Guronsan had increasing effect of mast cells. 2). On the injection of Moriamin-S, white blood cells were noticeably increased with increase of mast cells in blood, but mast cell: white cell ratio was not so remarkable; Moriamin-S had increasing effect of mast cells. 3). On the injection of Tespamin, white cells were decreased with slight decrease of mast cells in blood. c). Fluctuation of mast cells in blood was investigated after injection of Guronsan, Moriamin-S or Tespamin with each concomitant injection of ten per cent of cancer extract, and results obtained were as follows. 1). On the injections of Guronsan and cancer extract, mast cells in blood were far markedly increased, proving acceleration in the increase. 2). On the injections of Moriamin-S and cancer extract, they were also significantly increased; suppressive effect in the recovery after injection. 3). On the injections of Tespamin and cancer extract, mast cells were markedly increased, but white cells decreased with increase in mast cell: white cell ratio, and they were propelled in the recovery after injection. It was, by the results described above, concluded that the mast cells were definitely increased after injection of cancer extract.
ISSN
0030-1558
NCID
AN00032489