Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

昇汞の消毒作用並びに毒性に関する研究 第2編 昇汞の毒性並びに昇汞中毒に対する6,8-Dithiooctanoic Acidの効果に就いて

酒井 朝生 岡山大学医学部公衆衛生学教室
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For the purpose of determining the toxicity of mercuric chloride the author performed experiments to find out LD(50) of this compound with the mice given intraperitoneal injection of mercuric chloride solution and also experiments on the antidotal effect of 6.8-dithiooetanoic acid: and obtained the following results. 1. The LD(50) values determined by Van den Waerdens method are as follows: 1 day LD(50)=0.01116±0.00102mg 2 day LD(50)=0.00997±0.001036mg 3 day LD(50)=0.00837±0.00108mg 4 day LD(50)=0.00712±0.00109mg 5 day LD(50)=0.0064±0.00109mg 6 day LD(50)=0.00574±0.00125mg 2. When 6.8-dithiooctanoic acid is injected to mice prior to intraperitoneal injection of the mercuric chloride solution, it has been found that fatality rate and toxic symptoms (adecrease in the erythrocyte count and an increase in the leucocyte count) are somewhat suppressed.