Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

脳のアミノ酸代謝に関する研究 第I編 グルタミン酸およびγ-アミノ酪酸の脳内変動に関する研究

国土 忠男 岡山大学医学部第1(陣内)外科教室
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抄録
The amount of glutamic acid and γ-aminobutyric acid in rabbit brain and human cerebral cortex under various conditions were determined by paperchromatography. The results were as follows: 1) After convulsion caused by electro-shock, the contents of glutamic acid and γ-aminobutyric acid in the rabbit brain markedly decreased. 2) In rabbits with repeated convulsions caused by electroshocks for 10 days (5 times every day), the contents of glutamic acid and γ-aminobutyric acid showed a decrease. 3) After the injection of chlorpromazin (50 mg/kg per time), the contents of glutamic acid and γ-aminobutyric acid decreased. 4) The contents of glutamic acid and γ-aminobutyric acid in the cerebral cortex of epilepsia were less as compared with non-epileptic patients (patients with brain tumor).
ISSN
0030-1558
NCID
AN00032489