1) As for groups of disfunctional adrenal cortex, three groups were studied i.e. interrupted group, unilateral exstirpation group and bilateral exstirpation group, after SCHEROSON's continuing injection. In each case, the decreasing ratio of eosinophile leukocytes by Thorn-test became small, the duration of anesthesia prolonged and in respect to histochemical figures or weight of adrenalin, it showed hypofunction. Especially it was marked in the group of bilateral exstirpation. 2) As for the hyperfunction of adrenal cortex and protecting group two groups, continuing injection of ACTH and Insulin with 5% dextrose, were studied. In each case the decreasing ratio of eosinophile leukocytes by Thorn-test became larger and the duration of anesthesia reduced. In respect to histochemical figures and weight of adrenalin, it showed hyperfunction. Especially, it was marked in the case of injecting with Insulindextrose. 3) As for the sexual hormone injection group, Androgen and Estrogen injection groups were studied. The decreasing ratio of eosinophile leukocytes by Thorn-test was small when Androgen was used and was large when Estrogen was used. The duration of anesthesia was prolonged in the former and was shortened in the latter. The histochemical figures and the weight of adrenalin showed hypofunction in the former and hyperfunction in the latter.