Journal of Okayama Medical Association
Published by Okayama Medical Association

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Azo蛋白質の血清学的研究 第3編 Atoxyl-azo-蛋白質の正常時並びにAnaphylaxie Schock時に於ける生体内分布について

歯朶尾 正幸 岡山大学医学部公衆衛生学教室
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抄録
The anther refined atoxyl-azo-human serum albumin and gave it as the antigen to a guinea-pig and obtained the following results on its distribution in the body and the excretion into the excrements. 1) Storages of the antigen given to the animal by the venous injection show the highest amounts at each oragans in 8 hours after the injection, and the ascending arrangement of the amount is this: - liver, bone marrow, kidney, spleen and abdominal lymphatic gland - and specially much at reticuloendothelial system. 2) In case of the abdominal injection, the highest storages at each organs are in 12 hours after the injection: and much at the abdominal lymphatic gland and some at liver, spleen and kidney and only a little at reticuloendothelial system. 3) In case of the hypodermic injection, the highest storage at each organs are in 24 hours after the injection and very a little distrbution is shown at reticuloendothelial system. 4) The antigen concentration in the blood and its excretion into the excrements are parallel each other. 5) The distribution and storage of the antigen in a cell are the most at mitochondria, the next microsome and the next nucleus. 6) The excretion of arsenic into the dung of I gramme is always more than that of the urine of I gramme. 7) The antigen amount given by the venous injection has been excreted into the excrements in II days, and in 15 days arsenic not seen. 8) The antigen is distributed to a lung much specially at the test of the anaphylactic shock death compared with a standard example and the higher degree of anaphylactic occures, the more distribution is held on.
ISSN
0030-1558
NCID
AN00032489