Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

脳コリンエステラーゼにおよぼすアミノ酸の影響に関する研究 第1編 真性癲癇大脳皮質のコリンエステラーゼ活性におよぼすアミノ酸の影響について

山口 廸哉 岡山大学医学部第1(陣内)外科教室
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The ChE activity of cerebral cortex resected from idiopathic epileptics and non-epilcptics and the influences of glutamic acid, glutamine, aspartic acid, asparagine, γ-aminobutyric acid and γ-amino-β-hydrooxybutyric acid were studied. 1) In the brain of idiopathic epileptics, ChE activity is more markedly accelerated than that in the brain of non-epileptics. 2) By adding the amino-acids mentioned above, restraint occurs in each case. The intensity of these restraint for the non-epilcptic brain has the order of asparagine, glutamine, γ-amino-β-hydroxybutyric acid, glutamic acid, aspartic acid, glutamine. γ-aminobutyric acid, while that for idiopathic epileptic brain it is asparagine, aspartic acid, glutamine, γ-amino-β-hydroxybutyric acid, glutamic acid γ-aminobutyric acid. 3) The reduction of ChE activity by adding amino acids is found in each case of epileptic and non-epileptic brain. But it is not so definite in epileptic brain as in none-epileptic brain. 4) The ascending of ChE activity in idiopathic epileptic brain is regarded to be caused by the reduction of free amino acids in idiopathic brain.