1) The increased cholinesterase activity coursed by administration of Acetylcholine, pilocarpine, Imidalin and chloromazine reduce the concentration of pentothel in the Brain and Serum. 2) The decreased cholinesterase actriity coursed by administration of physostigmin, prostigmin and DFP increase the concentration of pentothal in the Brain and Serum. 3) The mutation of distribution of pentothal in the Body coursed by administration of Ephedrin, Epinephrin and Norepinephrin should be attributable to both increased Blood pressure and reduced cholinesterase activity. 4) The mutation of anaesthetic duration and the distribution of pentothal in the body changed by administration of various drugs of autenomic nervous system should be attributable to both cholinesterase activity and Blood pressure influenced by these drugs.