Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

脳mitochondriaのT. C. A. cycleに関する研究 第2編 真正癲癇および非癲癇患者大脳皮質mitochondriaのT. C. A. cycleに関する研究

樋口 慎之助 岡山大学医学部第1(陣内)外科教室
Thumnail 71_1563.pdf 404 KB
The respiration of human brain mitochondria was measured by the Warburg's manometer and the members of the TCA cycle were used as the substrate. The O(2)-uptake of the non-epileptic brain mitochondria is about on and half times of the epileptic brain mitochondria. On the oxidation of the substrate: Malate, fumarate, pyruvate, oxalacetate and α-ketoglutarate accelerate the O(2)-uptake in both cases, and the O(2)-uptake of non-epileptic cases are always 2 or 3 times of the epileptic cases. Citrate accelerate the O(2)-uptake in the non-epileptic case, but not in the epileptic case. Succinate accelerate the O(2)-uptake in both cases and its about several times of the other substrate. Especially the increase of the O(2)-uptake of the epileptic brain mitochondria by succinate is higher than of the non-epileptic brain mitochondria.