In the cases of inadequate heterotrasfusion with 13～15cc. of blood per kg every rabbit showed marked hypolention and 2 cases died in 5 cases. And the serum calium content was decreased, the surum mucleic acid content, both RNA and DNA, was increased by the shock. These ill effects were restrained by Ravonal, Anergen and Contomin. From the above mentioned facts it is considered that, the inhibition of Ravonal, Anergen and Contomin to ill effects of inspecific or inadequate heterotransfusion is primarily not due to their inhibiting action to the hemolysis, but to that to the shock of hemolytic toxin, by depresing organ-metabolism hemolysis itself, but to the shock of hemolytic toxin by the descending of organ-metabolism.