Gastric ulcer induced by oophorectomy and adrenalectomy has been found to have close relationships with abnormalities in blood components and its relationships was similar to that in adrenalectomy alone. Ulcer produced by adrenalectomy and hypophysectomy was mechanically complicated than that in adrenalectomy alone. In this case, prevention of ulcerformation was impossible by oral administration of 1% NaCl solution or substitution therapy utillizing cortisone and could be prevented by oral administration of glucose with substitution therapy utilizing cortisone or by vagotomy. When adrenalectomy and hypophysectomy were performed on vagotomized adults rats, no abnormalities in blood components, particularly serum K, Na and blood sugar, were founded, in the literatures. Therfore, it would be said that, the metabolism of blood sugar is also one of the most important factors in the formation of gastric ulcer due to hormonal disharmony, and that the concept of "gastric ulcer due to hormonal disharmony" could also be applied to "gastric ulcer due to founctional disorder of pituitary-adrenal system".