With the purpose to clarify the movement of antibody, which was reacted to the extracted antigen of human liver with physiological salt solution identified in the serum of epidemic hepatitis patient, in vivo, the auther studied the presence of antibody to the liver antigen and it's vicissitude in the rabbite with the experimental liver damage occured from the sensitization by homologous liver, the administration of homologous anti-liver serum and various drugs. And the results were as follows. 1. The author sensitized homologous animal (rabbit) by the extracted antigen of rabbit's liver with physiological salt solution and phosphatide of rabbit's liver and certified the production of homologous antibody by the precipitation test. 2. The production of auto-liver antibody by the liver damage originated from the relative peculiarity of organ was observed on the administration of antiserum of rabbit's liver into homologous animal (rabbit). 3. Comparing the sensitization of homologous animal (rabbit) by homologous liver phosphatide with that by homologous liver emulsion with physiological salt solution, the pathological picture (Necrosis of liver cells, degeneration of nucleus, edema and multiplication of stroma, infiltration of leukocyte, swelling and multiplication of star cells) of the former was remarkable, but no remarkable difference between the pathological pictures of their livers was observed on the administration of anti-liver serum, obtained from the above treatment, into homologous animal (rabbit). 4. The appearance of antibody to the extracted antigen of hemologous liver with physiological salt solution was identified in parallel with liver function damage and leucocytosis of the animal on the occurence of experimental liver damge by various drugs (carbon tetrachloride, chloroform and formic acid allyl).