Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

Diamoxの抗痙攣効果に関する研究 第2編 Diamoxの脳髄遊離アミノ窒素に及ぼす影響

河原 佳正 岡山大学医学部第1(陣内)外科教室
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The effects of Diamox on the free amino nitrogen in cats brain were measured The experiments were performed by Van-Slyke method taking the samples at 9 and 24 house respectively after the injection of Diamox. Concerning about the mean values of each 8 cases, the free aminonitrogen showed 25.9% increase at 9 hours, while 37.3% decrease at 24 house than the normal values. The anticonvulsive effects of Diamox were considered to be based on the ammonium management accompanying with the increases of glutamic acid. On the contrary, the decreases of the free amino nitrogen were considered to be based on the lack of the sources of glutamic acid synthesis.