Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

脳mitochondriaのT.C.A. cycleに関する研究 第1編 正常家兎および潜在性脳局所アナフイラキシー家兎大脳皮質mitochondriaのT.C.A. cycleに関する研究

樋口 愼之助 岡山大学医学部第1(陣内)外科教室
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1. The respiration of mitochondria was measured by the Warburg's manometer and the intermediates of the TCA cycle were used as the substrates. 2. The O(2)-uptake of the normal rabbit brain mitchondria is about twice of the rabbit mitochondria with latent cerebral local anaphylaxis. 3. On the stimulation of the substrate; The succinate, α-ketoglutarate, oxalacetate and pyruvate accelerate the O(2)-uptake in both cases, but the O(2)-uptake of the normal brain is always more than that with anaphylaxis. 4. Fumarate stimulates the O(2)-uptake of the normal brain, but does not stimulate that with anaphylaxis. 5. Citrate and malate do not accelerate in both cases.