Journal of Okayama Medical Association
Published by Okayama Medical Association

Full-text articles are available 3 years after publication.

腸チフス菌S,R型変異に関する研究 第二編 腸チフスS型菌から抽出した核酸,DNA,蛋白質(endotoxin)及び多糖体(hapten)のR型菌の呼吸に及ぼす影響

広瀬 温 岡山大学医学部微生物学教室
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Studies on the metabolism, particularly of the oxidation of the Typhoid bacillus caused by these four substances. Analytic determination made of the amount of oxygen consumption of Salmonellas 57R and 58R cultured on synthetic media, by using Glucose, Gluconic acid, Phospho-glyceric acid, Lactate, Pyruvate, Acetate, Saccinate and Glutamate as the basic substances, by means of the Warburg manometer. The results were as follows. 1) The said four substances extracted from Salmonella 57R had not any influence like the smooth type upon the rough type. 2) Nucleic acid, Des-oxy-ribo-nucleic acid and Polypeptide extracted from Salmonellas 57S and 58S, and Salmonella typhi Nakagawa and Salmonella typhi Murakami had considerable effect and accelerated either oxidation like the smooth type or beyond the smooth type upon the rough type, nevertheless Polysaccharide had only a little influence upon them. 3) Acceleration of the oxidation due to these four substances seemed to begin in about 40 minutes. 4) No difference was to be noted by an amount added of these substances.