Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

肝細胞癌症例および非坦癌肝硬変症例にみられる血漿リン脂質多価不飽和脂肪酸形成の異常と臨床の意義

横山 純子 Department of Medicine and Medical Science, Okayama University Graduate School of Medicine and Dentistry
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抄録
The aim of present syudy is to analyze fatty acid composition in plasma phospolipids in patients with hepatocellular carcinoma (HCC) and live cirrhosis (LC) and to elucidate the significance of polunsaturated fatty acid on hepatocarcinogenesis. Arachidonic acid/Linoleic acid (AA/LA) molar ratios in plasma phosphatidylinositol in LC (1.42±0.29,p<0.01) and in HCC (1.24±0.12,p<0.001) were significantly lower than that in control subjects (2.78±0.16). The AA/LA molar ratio in plasma phoshatidylethanolamine in HCC(1.07±0.13) was significantly lower than that in control subjecls (1.94±0.21,p<0.01). The plasma lysophospatidyclholine (LysoPC) concentration in HCC (71.6±8.4nmol/ml, p<0.001) and in LC(80.9±12.0 nmol/ml, p<0.001) were siginificantly lower than that in control subjects (146.7±5.7nmol/ml). Plasma arachidonoy-LysoPC was siginificantly in HCC(3.2±0.5mol%) compared with that in LC (1.5±0.3mol%,p<0.01) and in control subjecys (1.9±0.1mol%,p<0.01). Plasma arachidonoy-LysoPC may play an importhant role in the pathophysiology of HCC patients.
キーワード
plasma phospholipids
arachidonic acird
lysophosphatidylcholine
hepatocellular carcinoma
liver chrrhosis
備考
原著論文
ISSN
0030-1558
NCID
AN00032489