Journal of Okayama Medical Association
Published by Okayama Medical Association

<Availability>
Full-text articles are available 3 years after publication.

抗リン脂質抗体症候群における動脈血栓の発症機序:β2-グリコプロテインIに特異的なリガンドと自己抗体の関与

劉 慶平 岡山大学院医歯学総合研究科細胞化学分野
Thumnail 114_39.pdf 3.65 MB
抄録
β2-Glycoprotein I (β2-GPI) is a major antigen for anticardiolipin antibodies (aCL) appeared in patients with antiphospholipid syndrome (APS). We recently reported that β2-GPI specifically binds to oxidized low-density lipoprotein (oxLDL) and that on of the β2-GPI's major ligands derived from oxLDL, oxLig-1, is 9-(7-ketocholest-5-en-3β-yloxy)-9-oxononanoic acid (J. Lipid Res. 42, 697, 2001). In the present study, it was demonstrated that carboxylated variants of cholesteryl linoleate have a critical role for β2-GPI binding.In vitro experiments indicate that oxLDL was uptaken by macrophages via an interaction among the ligand such as oxLig-1, β2-GPI, and anti-β2-GPI autoantibodies. The uptake was not occurred by cholesterol or its ester without a free carboxyl residue, i.e., cholesteryl lenoleate, by cholesterol, or by 7-ketocholesterol alone, even in the presence of β2-GPI and anti-β2-GPI antibodies. Thus, carboxyl variants of cholesteryl ester specific for β2-GPI may mediate anti-β2-GPI Ab-dependent uptake of oxLDL by macrophages and autoimmune atherogenesis developed in APS.
キーワード
antiphospholipid syndrome (APS)
atherosclerosis
autoantibody
β2-glycoprotein I (β2-GPI)
oxidized LDL (oxLDL)
備考
原著論文
ISSN
0030-1558
NCID
AN00032489