Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

尿路感染症治療における Granulocyte Colony-Stimulating Factor (G-CSF) の有用性に関する基礎的検討

畠 和宏 岡山大学医学部泌尿器科学教室
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抄録
The priming effects of granulocyte colony stimulating factor (G-CSF) on neutrophil function and anti-pseudomonal activity were examined under various osmotic conditions created with urea and NaCL (280mOsm., 400mOsm., 800mOsm.) in vitro. Consequently, the prophylactic effect of G-CSF on post-operative urinary tract infection after transurethral resection of the prostate were examined experimentally. As a result, neutropil chemiluminescence was significantly enhanced by G-CSF under physiological osmotic conditions. However, enhancement was not observed under hyperosmotic conditions as in the urine. Similarly, the anti-pseudomonal activity of human neutrophils was not enhanced by G-CSF under hyperosmotic condition. However, whole blood chemiluminescence in patients after transurethral resection of the prostate was significantly enhanced by the administration of G-CSF. Moreover, postoperative urinary tract infection, considered an infection of the submucosal layer, was not obsereved, suggesting that the neutrophil priming effect occurred in the submucosal layer not in the urinary tract.
キーワード
urinary tract infection
G-CSF
chemiluminescence
neutrophil function
備考
原著
ISSN
0030-1558
NCID
AN00032489