Journal of Okayama Medical Association
Published by Okayama Medical Association

<Availability>
Full-text articles are available 3 years after publication.

N(G)-モノメチル-L-アルギニンの脈絡膜組織血流量への影響 第2報 D-アルギニンまたはL-アルギニンとの同時投与について

森 靖弘 岡山大学医学部眼科学教室
Thumnail 107_187.pdf 342 KB
抄録
Both N(G)-monomethyl-L-arginine (1.0×10(-5)mol/kg), which is the specific inhibitor of nitric oxide formation, and D-arginine (1.0×10(-4)mol/kg) or L-arginine (1.0×10(-4)mol/kg) were administered intravenously to albino rabbits under local anesthesia, and choroidal blood flow was measured by the hydrogen clearance method until 60 minutes after administration. The effect of N(G)-monomethyl-L-arginine, which caused vasoconstriction of the choroid, was partially reversed by the addition of L-arginine. These finidings suggest that the endothelium-derived relaxing factor from L-arginine participates in the regulation of choroidal blood flow.
キーワード
血管内皮由来弛緩因子
L-アルギニン
NG-モノメチル-L-アルギニン
脈絡膜組織血流量
水素クリアランス法
備考
原著
ISSN
0030-1558
NCID
AN00032489