We report a 75-year-old female with diabetes mellitus complicated with celiac arterial obliteration and hepatocellular cercinoma (HCC). She had been treated with diet therapy by her family doctor for essential hypertension and diabetes mellitus and was referred to our hospital because a space occupying lesion (SOL) was detected in the liver by abdominal CT examination. The SOL was confirmed as hepatocellular carcinoma by ultrasonography and magnetic resoance imaging. Celiac angiography revealed complete obliteration of the celiac artery probably due to diabetic macroangiopathy. Sine the deterioration of the liver function was not conspicuous, it was suggested that the development of HCC was affected by diabetes mellitus.