Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

ヒト赤血球系細胞の細胞内フェリチンに関する研究―成熟段階におけるトランスフェリン受容体及び可染性鉄との関係について―

花房 純弘 岡山大学医学部第二内科学教室
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抄録
To measure the intracellular ferritin (Ft) content in human erythroid cells, a new method was developed using human bone marrow amears. With this method, Ft, transferrin receptors (TfR) and stainable iron granules (SIG) were semiquantified at the single cell level and the cell's maturation level was identified. The relationship between Ft and other parameters was investigatted. Ft-H subunit concentrations were found to decrease with maturation from basophilic to orthochromatic erythroblasts (r=-0.62,p<0.05) and further decreased after denucleation. There was significant positive correlation between the Ft-H subunit concentra-tion and TfR density (r=0.52,p<0.01), but the relation between the Ft-L subunit and TfR or the density of SIG was obscure. These data indicate that : 1) The Ft-H subunit might play a more important role than the Ft-L subunit during iron metabolism and differentiation of erythroid cells. 2) Some factors other than intracellular iron levl, such as maturation, seem to play important roles in the Ft expression in erythroid cells.
キーワード
ferritin
erythroid cell
transferrin receptor
non-hemin iron
備考
原著
ISSN
0030-1558
NCID
AN00032489