Journal of Okayama Medical Association
Published by Okayama Medical Association

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ヒト血小板凝集能におけるセロトニン(2)およびアルファ(2)-アドレナージック受容体の薬理学的相互作用

岡田 英俊 岡山大学医学部脳代謝研究施設病態生化学部門
抄録
To investigate the interaction between serotonin (5HT)(2) and α(2)-adrenergic receptors in the human platelet membrane, the inhibitory effects of calcium (Ca) antagonists, 5HT(2) antagonists, α(2) antagonists and adenosine (AE) receptor (A(2)) agonists on 5HT plus ADP ([5HT+ADP]) and adrenaline (ADR) plus ADP ([ADR+ADP])-induced washed platelet aggregation were examined. In the [5HT+ADP] -induced aggregation. The inhibitory activity was in the order of (-)-desmethoxyverapamil (D888), mianserin (MA), ketanserin, AE>diltiazem, nicardipine, yohimbine. On the other hand, in the [ADR+ADP] -induced aggregation, the inhibitory activity was in the order of MA, YH>D888, AE, and the rest had no significant effect even at 10 μM. Only AE among these drugs inhibited ADP-induced aggregation. The present findings indicate that the Ca antagonist D888, 5HT(2) antagonist MA and α(2) antagonist YH acted simultaneously as 5HT(2) and α(2) receptor inhibitors and imply an apparent interaction between these receptors. Since both of the aggregation responses required extracellular Ca(2+) and were modulated by Ca(2+) concentrations, the mechanism of interaction may be attributed to intracellular Ca(2+)-signaling systems.
キーワード
platelet aggregation
serotonin(2) receptors
α(2)-adrenergic receptors
calcium antagonists
備考
原著
ISSN
0030-1558
NCID
AN00032489