Journal of Okayama Medical Association
Published by Okayama Medical Association

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エンドトキシンによるラット脳内メタロチオネイン遺伝子発現に関する研究

板野 義太郎 岡山大学医学部麻酔・蘇生学教室
Thumnail 103_117.pdf 8.33 MB
抄録
To clarify the acute-phase response in brain, we investigated the induction of metallothionein (MT) genes by administering an endotoxin (lipopolysaccharide) in rat intraperitoneum. We performed in situ hybridization on the serial brain sections to identify the cells expressing the MT genes in the acute-phase. After endotoxin administration, transcripts of MT genes were detected in the arachnoideal, ependymal cells and the Bergmann glia of the cerebellum, while no significant induction of the MT genes by zinc ion was observed in the brain. These results suggest that the acute-phase response occurs specifically in at least these three non-neuronal cells.
キーワード
メタロチオネイン
エンドトキシン
acute-phase
in situ hybridization
備考
原著
ISSN
0030-1558
NCID
AN00032489