Journal of Okayama Medical Association
Published by Okayama Medical Association

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無麻酔・無拘束下ラットの出血性低血圧モデルにおける内因性 Thyrotropin releasing hormone (TRH) の血圧維持作用ならびにその作用部位に関する実験的研究

宮崎 峰生 岡山大学医学部麻酔・蘇生学教室
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抄録
A pressor effect of TRH in hemorrhagic hypotensive rats was studied. First, TRH (1mg/kg, 2mg/kg, 5mg/kg), its analogue MK771 (0.2mg/kg) and anti-TRH antibody were given intravenously. The change in the mean arterial blood pressure (MAP) was observed. After administration of TRH, MAP rose dose-dependently, and it also rose after administration of MK771. The anti-TRH antibody significantly suppressed the compensatory and reflective increase of MAP following the hemorrhage. This suggested that the endogenous TRH plays an important role in the maintenance of MAP in the hemorrhagic hypotensive state. Next, the same hypotention models were made using adreno-demedullated rats. TRH or anti-TRH antibody was given intravenously. TRH significantly increased MAP, while the anti-TRH antibody suppressed MAP. This indicates that the pressor effect of TRH is not mediated by the adrenal medulla. The endogenous TRH may play its maintenance role of blood pressure via medulla oblongata.
キーワード
出血性低血圧
TRH
MK771
抗 TRH 抗体
副腎髄質除去ラット
備考
原著
ISSN
0030-1558
NCID
AN00032489