Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

高カロリー輸液における脂肪の配合比の研究―脂肪の燃焼率からみたエネルギー代謝の検討―

石川 治 岡山大学医学部第二外科学教室
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抄録
To investigate the efficacy of intravenous fat emulsion for total parenteral nutrition (TPN), oxidation of fat was evaluated using (14)C labeled nutrients in rats. Animals were divided into five group depending the content of fat emulsion of TPN e. i. 0%, 20%, 40%, 60%, and 80%, respectively. Oxidation rate of intravenous glucose was unaffected by content of fat emulsion. Cumulative (14)CO(2) production for 7 hours was about 62% in all groups. On the other hand, the oxidation rate of intravenous fat emulsion was suppressed by increased glucose content. There was a negative linear relationship between oxidation rate of intravenous fat and glucose intake (r=-0.92, p<0.01). The oxidation rate of intravenous fat was increased proportionaly to fat intake and not completely suppressed when fat-free TPN was provided. Percentage of energy to be infused as fat should be about 20%.
キーワード
高カロリー輸液
脂肪乳剤
(14)C-脂肪乳剤
呼気ガス代謝
ISSN
0030-1558
NCID
AN00032489