To reduce the side effects during hemodialysis treatment, we used FUT-175 (FUT), which has anticomplementary activity as an anticoagulant during hemodialysis. On 9 dialysis patients and 8 domestic rabbits, we used heparin or FUT as an anticoagulant during dialysis and studied their effects on anticoagulant action, white blood cell count, complement activity and lipid metabolism. FUT exerted a stronger local anticoagulant action than heparin. Although FUT did not suppress hemodialysis leukopenia, it suppressed complement activity. FUT suppressed the decrease in triglyceride and the increase in free fatty acids observed during heparin administration.
In conclusion, FUT could be an anticoagulant superior to heparin.