Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

透析療法における抗凝固剤の生体適合性

芳形 家山 岡山大学医学部第三内科学教室
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抄録
To reduce the side effects during hemodialysis treatment, we used FUT-175 (FUT), which has anticomplementary activity as an anticoagulant during hemodialysis. On 9 dialysis patients and 8 domestic rabbits, we used heparin or FUT as an anticoagulant during dialysis and studied their effects on anticoagulant action, white blood cell count, complement activity and lipid metabolism. FUT exerted a stronger local anticoagulant action than heparin. Although FUT did not suppress hemodialysis leukopenia, it suppressed complement activity. FUT suppressed the decrease in triglyceride and the increase in free fatty acids observed during heparin administration. In conclusion, FUT could be an anticoagulant superior to heparin.
キーワード
FUT透析
局所抗凝固作用
Hemodialysis leukopenia
抗補体活性
脂質代謝異常
ISSN
0030-1558
NCID
AN00032489