Journal of Okayama Medical Association
Published by Okayama Medical Association

<Availability>
Full-text articles are available 3 years after publication.

アデノウイルス誘発マウス腫瘍における myc 群癌遺伝子の増幅と発現

沖野 毅 香川医科大学病理学講座第一病理学
Thumnail 102_209.pdf 3.69 MB
抄録
Amplification and expression of myc-related oncogenes were studied on adenovirus-induced tumors (D and IC) and spontaneous hapatoma (P), all of which had been successively trans-planted in C3Hf/OK mice. c-myc expression waas elevated in the D, IC anf P tumors, and a 8.9-fold amplification of c-myc was observed in the IC tumor. In the D tumor N-myc expression was elevated and a 1.9-fold amplification of N-myc was also observed. Amplification of c-myc in the IC tumor was suspected to be a result of selection for c-myc amplified cells during successive transplantation. Although expression of genes, c-myc, N-myc and E1A of adenovir-us, suppress each other, the results of this experiment, especially elevated expression of N-myc and c-myc in the D tumor, implicated deregulation of myc family genes in malignancies indiced by adenovirus.
キーワード
アデノウイルス
癌遺伝子
c-myc
N-myc
ISSN
0030-1558
NCID
AN00032489