Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

急性白血病再燃病態並びに再燃予知に関する研究 第2編 急性白血病における血清IAP値と再燃予知に関する検討

滝沢 道弘 岡山大学医学部第二内科学教室
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抄録
Serum levels of immunosuppressive acidic protein (IAP) in 17 patients with acute leukemia were measured. The patients included 5 with acute myelocytic leukemia (AML), 4 with acute promyelocytic leukemia (APL), 3 with acute monocytic/myelomonocytic leukemia (AMoL/AMMoL), and 5 with acute lymphocytic leukemia (ALL). Serum IAP levels in untreated acute leukemia patients were higher than those in normal healthy individuals (763.2±321.1 ng/ml vs 389.8±96.7 ng/ml, p<0.05). They tended to decrease to a normal range in complete remission. A correlation was observed between serum IAP levels and the leukemic cell population in the bone marrow (r=0.39, p<0.05). Serum IAP levels increased in febrile patients compared to those in afebrile patients (p<0.05). Patients with more than 500ng/ml of IAP in remission had more risk of relapse in comparison to those with less than 500ng/ml (7 of 10, 70% vs 2 of 15, 13.3%, p<0.05). These results suggest that the measurement of serum IAP is useful for monitoring the leukemic patient.
キーワード
急性白血病
再燃病態
再燃予知
血清IAP値
ISSN
0030-1558
NCID
AN00032489