Journal of Okayama Medical Association
Published by Okayama Medical Association

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Full-text articles are available 3 years after publication.

気管支喘息におけるカリクレイン-キニン系に関する研究 第1編 気管支喘息と末梢血力リクレイン-キニン系の活性化についての検討

髙井 豊 岡山大学医学部第二内科学教室
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抄録
The relationship between bronchial asthma and Hageman factor dependent pathways (the contact phase of the internal coagulation system) was studied in reference to the possible role of the kallikrein-kinin system in asthmatics.The plasma Hageman factor level was significantly lower in asthmatics (74.8±27.7% in remission, and 75.4±26.3% during in attack) than in healthy subjects (98.1±27.6%), and the plasma prekallikrein value was also lower in asthmatics (88.8±25.3% in remission, and 75.1±23.8% during in attack) than in normal controls (105.7±19.7%). Especially, the plasma prekallikrein level was significantly lower in asthmatics during in attack than in those in remission. The plasma bradykinin level of asthmatics in remission tended to be higher (98.8±89.8pg/ml) than that of healthy subjects (47.1±29.6pg/ml). The plasma high molecular weight kininogen level was not significantly different between asthmatics and normal subjects. These results suggest that the plasma kallikrein-kinin system may play a role in the pathophysiology of bronchial asthma.
キーワード
bronchial asthma
Hageman factor dependent pathways
kallikrein-kinin system
atopic asthma
intractable asthma
ISSN
0030-1558
NCID
AN00032489