Journal of Okayama Medical Association
Published by Okayama Medical Association

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細菌細胞膜に含まれるカルジオリピンの抗原性とその抗体の細菌に対する反応性

中村 知明 岡山大学医学部細菌学教室
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抄録
I investigated the possibility of production of antibody to bacterial membrane-cardiolipin using cardiolipin micelles, Staphylococcus aureus (S.aureus) and L-form of S. aureus. I also investigated and the reactivity of anti-cardiolipin (CL) antibody with bacteria and DNA.I confirmed that the bacterial membrane-cardiolipin induced the production of anti-CL antibody, which was present mainly in the IgM fraction, but also in the IgG fraction.The anti-CL antibody reacted with L-form of bacteria and bacterial membrane fractions, but it did not react with the vegetative form of bacteria other than S. aureus nor with DNA. On the basis of these findings, I considered that the L-form of bacteria or fragments of bacterial membranes can be detected by immunofluorescence antibody technique or nitrocellulose membrane-enzyme immunoassay using the anti-CL antibody.
キーワード
カルジオリピン
抗カルジオリピン抗体
抗細菌細胞膜抗体
L型菌
抗DNA抗体
ISSN
0030-1558
NCID
AN00032489