岡山大学環境理工学部研究報告 ISSN 2187-6940
Published by Faculty of Environmental Science and Technology, Okayama University

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Binary data on radiation-related brain damage prenatally exposed and statistical threshold model

大竹 正德 岡山大学
田中 豊 岡山大学
Lee Sunghee 岡山大学
抄録
Exposure to ionizing radiation has been testified to have harmful effects on the developing human brain, particularly in the highly vulnerable period of 8-15 weeks after ovulation as an incereased frequency of severe mental retardation. However, the distribution of cases of severe mental retardation suggests a threshold in the low dose region. Data are composed of a binary (1,0) for mentally retarded or normal individuals. The statistical approaches with a threshold are conceivable for a simple, odds, logistic and Gompertz regression models. Estimation of threshold and 100(1-α)% confidence limits are derived from the maximum likelihood technique based on a profile approach.
キーワード
mental retardation
threshold model
prenatal exposure
profile approach
atomic bombings
ISSN
1341-9099
NCID
AN10529213
NAID