Acta Medica Okayama 72巻 3号
2018-06 発行

Randomized Phase II Study Comparing Mannitol with Furosemide for the Prevention of Renal Toxicity Induced by Cisplatin-based Chemotherapy with Short-term Low-volume Hydration in Advanced Non-small Cell Lung Cancer: The OLCSG1406 Study Protocol

Makimoto, Go Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,
Ichihara, Eiki Department of Allergy and Respiratory Medicine, Okayama University Hospital
Hotta, Katsuyuki Center of Innovative Clinical Medicine, Okayama University Hospital
Ninomiya, Kiichiro Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,
Oze, Isao Division of Epidemiology and Prevention, Aichi Cancer Center
Minami, Daisuke Department of Respiratory Medicine, Okayama Medical Center
Ninomiya, Takashi Department of Allergy and Respiratory Medicine, Okayama University Hospital
Kubo, Toshio Center for Clinical Oncology, Okayama University Hospital
Ohashi, Kadoaki Department of Allergy and Respiratory Medicine, Okayama University Hospital
Tabata, Masahiro Center for Clinical Oncology, Okayama University Hospital
Maeda, Yoshinobu Department of Hematology, Oncology, and Respiratory Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,
Kiura, Katsuyuki Department of Allergy and Respiratory Medicine, Okayama University Hospital
Publication Date
2018-06
Abstract
Although cisplatin-based chemotherapy shows a survival advantage compared to carboplatin for treating advanced non-small cell lung cancer, high-volume hydration and a long infusion time are necessary to avoid nephrotoxicity, and cisplatin-based chemotherapy has been difficult to administer in outpatient settings. A low-volume hydration method using mannitol or furosemide as forced diuresis was recently introduced, but there are no clear conclusions regarding which agent should be used. We describe our ongoing randomized phase II trial (the OLCSG1406 Study) evaluating the efficacy of forced diuresis. This study will clarify whether mannitol or furosemide is more suitable in cisplatin-based chemotherapy with low-volume hydration.
Document Type
Clinical Study Protocol
Keywords
cisplatin
mannitol
furosemide
lung cancer
hydration
non-small cell lung cancer
Link to PubMed
Thumnail 72_3_319.pdf 1.99 MB