Acta Medica Okayama 72巻 3号
2018-06 発行

Pulmonary Tumor Thrombotic Microangiopathy Induced by Prostate Cancer

Katayama, Satoshi Department of Urology, St.Mary's Hospital
Takenaka, Tadasu Department of Urology, Red Cross Okayama Hospital
Nakamura, Aya Department of Urology, Okayama Saiseikai General Hospital
Sako, Sinichi Department of Urology, Okayama Saiseikai General Hospital
Bessho, Akihiro Department of Respiratory Medicine, Red Cross Okayama Hospital
Ohara, Nobuya Department of Pathology, Kagawa Rosai Hospital
Publication Date
Pulmonary tumor thrombotic microangiopathy (PTTM) is a fatal, malignancy-related respiratory complication; we herein report a PTTM case induced by metastatic prostate cancer. An 81-year-old Japanese man developed dyspnea. High-resolution computed tomography (HRCT) revealed ground-glass opacities spread across bilateral lung fields. Pulmonary microvascular aspiration cytology detected prostate cancer cells. As PTTM was highly suspected, docetaxel chemotherapy was performed immediately. His respiratory condition and HRCT findings improved temporarily, but he died approx. 6 weeks after admission. Autopsy showed fibrocellular intimal proliferation of small pulmonary arterioles, which confirmed the diagnosis of PTTM induced by prostate cancer. As in the present case, it is often difficult to confirm the presence of not only tumor embolization but also fibrocellular intimal proliferation before the patient’s death.
Document Type
Case Report
prostate neoplasm
metastatic lung cancer
thrombotic microangiopathy
Link to PubMed
Thumnail 72_3_309.pdf 7.26 MB