PhysRevE_96_4_042410_a.pdf 1.23 MB
Sumi, Tomonari Research Institute for Interdisciplinary Science and Department of Chemistry, Faculty of Science, Okayama University ORCID Kaken ID publons researchmap
Okumoto, Atsushi Department of Computer Science and Engineering, Graduate School of Engineering, Toyohashi University of Technology
Goto, Hitoshi Department of Computer Science and Engineering, Graduate School of Engineering, Toyohashi University of Technology
Sekino, Hideo Department of Computer Science and Engineering, Graduate School of Engineering, Toyohashi University of Technology
A two-step subdiffusion behavior of lateral movement of transmembrane proteins in plasma membranes has been observed by using single-molecule experiments. A nested double-compartment model where large compartments are divided into several smaller ones has been proposed in order to explain this observation. These compartments are considered to be delimited by membrane-skeleton "fences" and membrane-protein "pickets" bound to the fences. We perform numerical simulations of a master equation using a simple two-dimensional lattice model to investigate the heterogeneous diffusion dynamics behavior of transmembrane proteins within plasma membranes. We show that the experimentally observed two-step subdiffusion process can be described using fence and picket models combined with decreased local diffusivity of transmembrane proteins in the vicinity of the pickets. This allows us to explain the two-step subdiffusion behavior without explicitly introducing nested double compartments.
Physical review. E.
American Physical Society
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Numerical calculation on a two-step subdiffusion behavior of lateral protein movement in plasma membranes Tomonari Sumi, Atsushi Okumoto, Hitoshi Goto, and Hideo Sekino Phys. Rev. E 96, 042410