ID 53121
JaLCDOI
フルテキストURL
69_1_45.pdf 274 KB
著者
Iida, Tadayuki Department of Physical Therapy, Faculty of Health and Welfare, Department of Prefectural University of Hiroshima
Inoue, Ken Department of Public Health, Faculty of Medicine, Shimane University
Ito, Yasuhiro Health Sciences, Fujita Health University,
Ishikawa, Hiroaki Health Sciences, Fujita Health University,
Kagiono, Miwa Gifu University of Medical Science
Teradaira, Ryoji Health Sciences, Fujita Health University,
Chikamura, Chiho Attached Clinic, Department of Prefectural University of Hiroshima
Harada, Toshihide Department of Physical Therapy, Faculty of Health and Welfare, Department of Prefectural University of Hiroshima
Ezoe, Satoko Shimane University Health Service Center Izumo
Yatsuya, Hiroshi Department of Public Health, Fujita Health University School of Medicine
抄録
This study aimed to clarify the association between depressive symptoms and a marker of oxidative stress-induced DNA damage in young females. Since the menstrual cycle may confound or modify this association, depressive symptoms and urinary levels of 8-hydroxy-2ʼ deoxyguanosine (8-OHdG) were evaluated during each menstrual phase. A total of 57 female fourth-year students (aged 21.6±0.8) from a Japanese health science university were studied. The menstrual cycle was divided into 3 phases:menstrual (days 1 to 3 after the onset of menses);proliferative (days 13 to 15);and secretory (days 24 to 26). Depressive symptoms were assessed by the self-rating depression scale (SDS). Positive depressive symptoms were defined as a score of 53 or more during 2 different menstrual phases. The association between the presence of depressive symptoms and 8-OHdG levels adjusting for the menstrual cycle was examined by two-way analysis of variance with the menstrual cycle (menstrual, proliferative, and secretory phases) as the within-individual factor. The menstrual cycle did not show a significant correlation with urinary 8-OHdG levels. On the other hand, the menstrual cycle-adjusted 8-OHdG level was significantly higher in those with depressive symptoms (7.01ng/mL) than in those without them (3.98ng/mL). The ROC curve analysis showed that urinary 8-OHdG levels had reasonably high discriminative performance throughout all the menstrual cycles (0.73-0.81;all p<0.05). These results indicated the presence of oxidative stress in subjects with depressive symptoms independent of the menstrual cycle.
キーワード
depression
8-OHdG
menstrual cycle
Amo Type
Original Article
発行日
2015-02
出版物タイトル
Acta Medica Okayama
69巻
1号
出版者
Okayama University Medical School
開始ページ
45
終了ページ
50
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2015 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Science KeyUT
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