ID | 53121 |
JaLCDOI | |
フルテキストURL | |
著者 |
Iida, Tadayuki
Department of Physical Therapy, Faculty of Health and Welfare, Department of Prefectural University of Hiroshima
Inoue, Ken
Department of Public Health, Faculty of Medicine, Shimane University
Ito, Yasuhiro
Health Sciences, Fujita Health University,
Ishikawa, Hiroaki
Health Sciences, Fujita Health University,
Kagiono, Miwa
Gifu University of Medical Science
Teradaira, Ryoji
Health Sciences, Fujita Health University,
Chikamura, Chiho
Attached Clinic, Department of Prefectural University of Hiroshima
Harada, Toshihide
Department of Physical Therapy, Faculty of Health and Welfare, Department of Prefectural University of Hiroshima
Ezoe, Satoko
Shimane University Health Service Center Izumo
Yatsuya, Hiroshi
Department of Public Health, Fujita Health University School of Medicine
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抄録 | This study aimed to clarify the association between depressive symptoms and a marker of oxidative stress-induced DNA damage in young females. Since the menstrual cycle may confound or modify this association, depressive symptoms and urinary levels of 8-hydroxy-2ʼ deoxyguanosine (8-OHdG) were evaluated during each menstrual phase. A total of 57 female fourth-year students (aged 21.6±0.8) from a Japanese health science university were studied. The menstrual cycle was divided into 3 phases:menstrual (days 1 to 3 after the onset of menses);proliferative (days 13 to 15);and secretory (days 24 to 26). Depressive symptoms were assessed by the self-rating depression scale (SDS). Positive depressive symptoms were defined as a score of 53 or more during 2 different menstrual phases. The association between the presence of depressive symptoms and 8-OHdG levels adjusting for the menstrual cycle was examined by two-way analysis of variance with the menstrual cycle (menstrual, proliferative, and secretory phases) as the within-individual factor. The menstrual cycle did not show a significant correlation with urinary 8-OHdG levels. On the other hand, the menstrual cycle-adjusted 8-OHdG level was significantly higher in those with depressive symptoms (7.01ng/mL) than in those without them (3.98ng/mL). The ROC curve analysis showed that urinary 8-OHdG levels had reasonably high discriminative performance throughout all the menstrual cycles (0.73-0.81;all p<0.05). These results indicated the presence of oxidative stress in subjects with depressive symptoms independent of the menstrual cycle.
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キーワード | depression
8-OHdG
menstrual cycle
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Amo Type | Original Article
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出版物タイトル |
Acta Medica Okayama
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発行日 | 2015-02
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巻 | 69巻
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号 | 1号
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出版者 | Okayama University Medical School
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開始ページ | 45
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終了ページ | 50
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ISSN | 0386-300X
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NCID | AA00508441
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資料タイプ |
学術雑誌論文
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言語 |
英語
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著作権者 | CopyrightⒸ 2015 by Okayama University Medical School
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論文のバージョン | publisher
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査読 |
有り
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PubMed ID | |
Web of Science KeyUT |