ID 48569
JaLCDOI
フルテキストURL
著者
Mizobuchi, Satoshi Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine
Matsuoka, Yoshikazu Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine
Obata, Norihiko Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine
Kaku, Ryuji Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine
Itano, Yoshitaro Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine
Tomotsuka, Naoto Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine
Taniguchi, Arata Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine
Nishie, Hiroyuki Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine
Kanzaki, Hirotaka Department of Biomedical Sciences, Cedars-sinai Medical Center
Ouchida, Mamoru Departments of Molecular Genetics, Okayama University Graduate School of Medicine
Morita, Kiyoshi Departments of Anesthesiology and Resuscitology, Okayama University Graduate School of Medicine
抄録
Perioperative beta-blocker administration has recently been recommended for patients undergoing cardiac or other surgery due to the beneficial cardiovascular effects of these agents. In addition, some studies have reported that perioperatively administered beta-blockers also have analgesic effects. In this study, to investigate the antinociceptive effects and the analgesic profile of landiolol, we examined the effects of intrathecal landiolol administration on nociceptive pain behavior and c-fos mRNA expression (a neural marker of pain) in the spinal cord using a rat formalin model. We found that pain-related behavior was inhibited by intrathecal landiolol administration. Moreover, the increase in c-fos mRNA expression on the formalin-injected side was less pronounced in rats administered landiolol than in saline administered controls. Thus, intrathecal administration of landiolol exhibited antinociceptive effects. Further investigation of the antinociceptive mechanism of landiolol is required.
キーワード
beta-blocker
landiolol
formalin
pain behavior
c-fos
Amo Type
Original Article
発行日
2012-06
出版物タイトル
Acta Medica Okayama
66巻
3号
出版者
Okayama University Medical School
開始ページ
285
終了ページ
289
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
著作権者
CopyrightⒸ 2012 by Okayama University Medical School
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT
過去1年のアクセス数
アクセス数 : ?
ダウンロード数 : ?

今月のアクセス数
アクセス数 : ?
ダウンロード数 : ?