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ID 42973
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タイトル(別表記)
Studies on Synthetic Anthelmintics Part 3. Anthelmintic Studies on Alkylresorcinols and Alkylchlororesorcinols
著者
足利 三明 岡山大学医学部薬理学教室
抄録
1. Anthelmintic effect in vitro against human and hog ascaris was examined with a total of 27 kinds of 4-alkyl-, 4-alkyl-6-chloro-, 4-alkyl-6-bromo-, and 4-alkyl-2, 6-dichloro-resorcinols in 1:1,000 to 1 2,000 dilutions. Based on the results thereby obtained, 14 kinds of compounds of alkylresorcinol and alkylmonochlororesorcinol series were submitted to anthelmintic treatment in man and their effect was examined by the egg-counting and worm-counting methods. 2. The in vitro effect of alkylresorcinols and their monochloro derivatives was found to be the strongest in hexylresorcinol and became weaker with a larger or smaller number of carbon atoms in the alkyl group. Comparison of the corresponding compounds showed that the alkylresorcinols generally possessed a stronger action than their monochloro derivatives. 3. Anthelmintic effect of alkylrescrcinols in man was also the strongest in the hexyl compound, followed by amyl- and heptyl-resorcinols. In the monochloro derivatives, their anthelmintic effect did not follow the order of their in vitro effect, effect, stronger than hexylresorcinol (m. p. 68-69°) being shown by amyl-(m. p. 43-44°), hexyl-(m. p. 46-48°), heptyl-(m. p. 45-47°), and octyl-chlororesorcinols (m. p. 49-51.5°), as well as by cyclo-hexylchororesorcinol (m. p. 86-88°), whose non-chlorinated compound was totally ineffective. 4. Ascaridical effect of alkylresorcinols decreased by the introduction of one bromine or two chlorine atoms.
発行日
1954-05-31
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
66巻
5号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
985
終了ページ
993
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/66/5/66_5_985/_article/-char/ja/
言語
Japanese
OAI-PMH Set
岡山大学
著作権者
Copyright© 岡山医学会
論文のバージョン
publisher
査読
有り
Sort Key
16
Eprints Journal Name
joma