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ID 42751
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タイトル(別表記)
Experimental Study on the Anemia after Total Gastrectomy I. Report: On the Peripheral Blood Picture and Bone Marrow Picture
著者
松本 正宏 岡山大学医学部津田外科教室
抄録
Many had been said, from olden times, on the relation between digestive organ (esp. stomach) and hematopoiesis, and it has been much clarified in appreciation of the discovery of liver therapy for pernicious anemia by Minot and Murphy (1926), the dissertation of the in-and extrinsic factors theory by Castle and Townsend (1929), and of the studies of many other authorities. The atrophy of the stomach is responsible for the occurrence of anemia and it has been reported that the microcytic or pernicious anemia had often been observed after total gastrectomy in man. But in the animal there were no report of cases of pernicious anemia after total gastrectomy. The author has performed the animal experiment in rats, after resecting the right portion of stomach as Jacobson etc. had done and also the left portion of the stomach. That has been resulted the lack of storage and stirring of diet. In these rats were observed the blood picture of peripheral and of bone marrow for 400 days after operation. Results obtained as follows: 1) Gastrectomized rats gain in weight little in general, and the one losing weight dies earlier. The ocular conjunctiva changes in white and glistening of hair will be lost a little. Activity will be minimized and they show a tendency to have loose bowels. 2) Hemoglobin decreases highly and rapidly in relativly early postoperative days and redcell count drops gradually. Color index decreases and immature red cells increase in number, but leucocytes show no marked differential abnormalities in spite of increasing in number. 3) Normoblasts, esp. basophilic and polychromatic, increase in the bone marrow but it is mostly microcytic showing hindrance on ripening of erythrocytes. The author summarizes that the agastric anemia in rats is hypochromic and microcytic in nature without no exceptions and shows iron deficiency anemia.
備考
正誤表あり
発行日
1956-11-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
68巻
11号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
2039
終了ページ
2054
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/68/11/68_11_2039/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
OAI-PMH Set
岡山大学
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Sort Key
22
Eprints Journal Name
joma