ID 32214
JaLCDOI
フルテキストURL
著者
Arao, Yujiro Okayama University
Hatano, Atsushi The University of Tokushima
Yamada, Masao Okayama University
Uno, Fumio Niimi Women's College
Nii, Shiro Okayama University
抄録

In order to elucidate the mechanism of latent infection of herpes simplex virus (HSV), reactivatable latency of three avirulent strains (SKO-1B, -GCr Miyama, SKa) of HSV type 1 was comparatively examined in a mouse latency model. The SKO-1B strain showed high rate of virus reactivation from explanted trigeminal ganglia without n-butyrate enhancement, while the other two strains showed a very low rate of virus reactivation in the absence of n-butyrate. In the presence of n-butyrate, however, the rate of the -GCr Miyama strain jumped to a comparable level with that of SKO-1B, although the rate of SKa remained at a low level. A more precise follow-up experiment changing the virus dose highlighted the difference of the ability to reactivate from the latent state between SKO-1B and -GCr Miyama. Virus titer in trigeminal ganglia during acute phase, infectivity to cell lines of neural origin, and susceptibility to acyclovir and phosphonoacetate were assayed to know the reasons for the variation in the ability of reactivatable latency among these strains. It was concluded that the reduced infectivity to neural cells, and limited ability of reactivatable latency shown by the SKa strain could mainly be attributed to the deficiency of thymidine kinase activity.</P>

キーワード
herpes simplex virus type 1
neurovirulence
latency
reactivation
n-butyrate
Amo Type
Article
発行日
1991-02
出版物タイトル
Acta Medica Okayama
45巻
1号
出版者
Okayama University Medical School
開始ページ
43
終了ページ
47
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
論文のバージョン
publisher
査読
有り
Submission Path
amo/vol45/iss1/6
PubMed ID
Web of Sience KeyUT
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