ID 32208
JaLCDOI
フルテキストURL
著者
Hirasawa, Ryuto Okayama University
Hashimoto, Kozo Okayama University
Ota, Zensuke Okayama University
抄録

The role of alpha-1 adrenergic mechanism in the shaking stress-induced adrenocorticotropic hormone (ACTH), and plasma noradrenaline secretion and pressor response were investigated using conscious rats. We also studied whether or not central corticotropin releasing hormone (CRH) is involved in the shaking stress-induced ACTH secretion. The shaking stress caused significant elevations of plasma ACTH, noradrenaline, and systolic blood pressure. Intra-third ventricular administration of alpha-1 adrenergic blocker, bunazosin, inhibited the shaking stress-induced ACTH secretion, but did not alter stress-induced noradrenaline secretion and pressor response. Furthermore, intra-third ventricular administration of CRH antagonist, alpha-helical CRH, significantly attenuated stress-induced ACTH secretion. These results indicate that alpha-1 adrenergic pathway and CRH at least partly mediate the shaking stress-induced ACTH secretion.</P>

キーワード
shaking stress
adrenocorticotropic hormone
noradrenaline
alpha-adrenergic mechanism
blood pressure
Amo Type
Article
発行日
1991-06
出版物タイトル
Acta Medica Okayama
45巻
3号
出版者
Okayama University Medical School
開始ページ
141
終了ページ
145
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
OAI-PMH Set
岡山大学
論文のバージョン
publisher
査読
有り
Submission Path
amo/vol45/iss3/3
PubMed ID
Web of Sience KeyUT
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