ID 32184
JaLCDOI
フルテキストURL
著者
Hirasawa, Ryoto Okayama University
Hashimoto, Hozo Okayama University
Makino, Shinya Okayama University
Suemaru, Shuso Okayama University
Takao, Toshihiro Okayama University
Ota, Zensuke Okayama University
Hoshida, Yoshihiko Okayama University
Yoshino, Tadashi Okayama University
Akagi, Tadaatsu Okayama University
抄録

A 46-year-old woman with acromegaly and hyperthyroidism due to a pituitary adenoma. She had high serum thyroid-stimulating hormone (TSH) levels and very high serum growth hormone (GH) levels. Transsphenoidal removal of the tumor, post-operative irradiation, frontal craniotomy for removal of residual tumor and large-dose bromocriptine therapy were carried out consecutively. After therapy, serum GH levels gradually decreased, but not to the normal range, and serum TSH levels remained at inappropriately normal levels. Using immunoperoxidase techniques, GH-, TSH- and follicle-stimulating hormone (FSH)-containing cells were demonstrated in the adenoma. A long-acting somatostatin analogue (SMS 201-995, 600 micrograms/day) suppressed the serum GH level to the normal range with a concomitant suppression of TSH. Furthermore, the paradoxical serum GH responses to TRH and LH-RH were slightly improved. No important subjective side-effects were noted. Therefore, SMS 201-995 appeared to be a very effective drug in this patient with a GH- and TSH-producing pituitary tumor.</P>

キーワード
TSH- and GH - producing pituitary adenoma
acromegaly
heperthyroidism
somatostatin analogue (SMS 201-995)
Amo Type
Article
発行日
1991-04
出版物タイトル
Acta Medica Okayama
45巻
2号
出版者
Okayama University Medical School
開始ページ
107
終了ページ
115
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT
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