ID 32097
JaLCDOI
フルテキストURL
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著者
Koirala, Tirtha Raj Okayama University
Hayashi, Kazuhiko Tottori University, Tottori
Jin, Zaishun Okayama University
Onoda, Sachiyo Okayama University
Tanaka, Takehiro Okayama University
Oda, Wakako Okayama University
Ichimura, Koichi Okayama University
Ohara, Nobuya Okayama University
Oka, Takashi Okayama University
Yamada, Masao Okayama University
Yoshino, Tadashi Okayama University
抄録

Epstein-Barr virus (EBV)-related herpesvirus (Si-IIA-EBV) was serially transmitted for 3 passages from rabbit to rabbit of the opposite sex by blood transfusion, which subsequently induced virus-associated rabbit lymphomas. The virus could be transmitted by transfusion with 15-20 ml of whole blood (7/7) or irradiated blood (1/6) from the EBV-related virus-infected rabbits, but there was no transmission with transfusion of cell-free plasma (0/6) from the infected rabbits. Passive anti-EBV-VCA IgG (x 20 approximately x 10) titers decreased during the first 1-2 weeks in the transfused rabbits. The virus-transmitted rabbits showed a gradual increase in antibody titers ranging from peak titers of x 640 to x 2560 after 3 weeks of transfusion. The recipient origin of malignant lymphoma that developed in the first rabbit transfused by infected blood was confirmed by chromosomal analysis. This rabbit model thus shows that EBV-related herpesvirus is serially transmissible by blood transfusion and that transmission can not be completely prevented by irradiation of blood, but removal of blood cells is the best way to prevent transmission of EBV-related virus. Therefore, this animal model provides a convenient in vivo system for studies of the prevention and therapy of transfusion-related transmission of EBV and EBV-associated lymphoproliferative diseases in immunocompromised human beings.

キーワード
?Epstein-Barr virus(EBV)
rabbit
lymphoproliferative diseases
blood transfusion
Amo Type
Article
発行日
2004-04
出版物タイトル
Acta Medica Okayama
58巻
2号
出版者
Okayama University Medical School
開始ページ
67
終了ページ
74
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT
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