ID 31117
JaLCDOI
フルテキストURL
著者
Jin, Li Kagawa Medical School
Murakami, Tetuhide H Kagawa Medical School
Janjua, Najma a Kagawa Medical School
Hori, Yasuo Okayama University
抄録

The purpose of this study was to investigate the effects of topical treatment with zinc oxide (2.5%, 10%, 25% and 50%) and intraperitoneal treatment with diethyldithiocarbamate (DEDTC) (50 mg/kg, 500 mg/kg and 1,000 mg/kg) on the mitotic index of epidermal basal cells in incised and non-incised mouse skin. The present results showed that topical application of zinc oxide (25% and 50%) increased the mitotic index of epidermal basal cells in incised skin and non-incised skin. Conversely, intraperitoneal administration of DEDTC (500 mg/kg and 1,000 mg/kg) decreased the mitotic index, but only in the incised skin. These results suggest that mitosis of epidermal basal cells may be stimulated by the topical application of zinc oxide both in incised and non-incised mouse skin, and that it also may be inhibited by the intraperitoneal administration of DEDTC in incised mouse skin.

キーワード
zinc oxide
mitotic index
epidermal basal cells
mouse skin
Amo Type
Article
発行日
1994-10
出版物タイトル
Acta Medica Okayama
48巻
5号
出版者
Okayama University Medical School
開始ページ
231
終了ページ
236
ISSN
0386-300X
NCID
AA00508441
資料タイプ
学術雑誌論文
言語
English
論文のバージョン
publisher
査読
有り
PubMed ID
Web of Sience KeyUT
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