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ID 19321
Eprint ID
19321
フルテキストURL
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タイトル(別表記)
Experimental Studies on the Infectious Hepatitis Part 2 Studies on the phosphorus metabolism of the pathogene- inoculated mouse liver by Schmidt-Thanhauser's method
著者
田辺 憲也 岡山大学医学部微生物学教室
抄録
In the past few years, the pathogene of infectious hepatitis occured in Okayama prefecture was isolated, and the study of characteristics of its pathogene were carried out in our department. Previously the author observed the significant changes on nucleic acid fraction by the investigation of phosphorus metabolism of the pathogene-inoculated mouse liver and reported its results in part Ⅰ. The author studied further the phosphorous metabolism of DNA fraction and RNA-protein fraction after the fractionation of phophorous compound by the Schmidt-Thanhauser's method and obtained the following results, 1) The P(32) incorpoation into DNA fraction was increased at the 6th and 7th day of the inoculation, the maximum incorporation was found at the 12th and 13th day. However, the incorporations at the 22nd and 23rd day showed no difference against control group. Hence, the intense change of phosphorus metabolism was presumed to occur at the early stadium after the inoculation. 2) The P(32) incorporation into RNA-protein fraction was not increased at the early stadium, but the incorporation showed the maximum at the 12th and 13h day; the maximum incorporation indicated the occurence of increased specific or non-specific metabolism in the cell. At the late stadium, the difference in the incorporation between tested and control group was not observed. 3) In the dilution test of the pathogene, it was found the serious affection on phosphorus metabolism of mouse in the dilution of 10(-4) or 10(-6). 4) These results showed the similar tendencies in the phosphorus metabolism as part Ⅰ in which the study was carried out by means of Schneider's method. The occurence of increased phosphorus metabolism of DNA fraction at the early stage after inoculation presumablly indicated that the pathogene investigated contained DNA as main nucleic acid just alike animal viruses.
発行日
1959-03-15
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
71巻
3-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1585
終了ページ
1593
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/71/3-2/71_3-2_1585/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma