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ID 19271
Eprint ID
19271
フルテキストURL
70_3803.pdf 4.86 MB
タイトル(別表記)
Effects of Peptone, Sinomenine, Polyvinylpyrrolidone and Corbicula Extract on the Tissue Mast Cells in the Dog
著者
河本 昭二郎 岡山大学医学部薬理学教室
抄録
Tissue specimens were excised from the liver, spleen, and from the skin of back and lips of dogs before and after intravenous injection of Witte peptone, sinomenine, polyvinyl pyrrolidone (PVP) and corbicula extract, and the mast cells of these tissues were examined for comparative study of the effect of these substances. The disruption of mast cells in the liver tissue was extremely marked after injection of pepton, but the change in the skin mast cells was only slight. In contrast to this, after the injection of sinomenine and PVP the disruption of skin mast cells was marked, but the change in the liver tissue was slight. Mast cells of the spleen were only slightly disrupted by any of these drugs. In the lip skin changes of mast cells by PVP and sinomenine were stronger in the superficial region rather than in the deeper tissue. In the liver and skin tissues it was confirmed that the degree of morphological change of the mast cells is parallel with the percentage rate of histamine release. Corbicula extract did not bring about any change of mast cells in any of these organs above mentioned. This substance simulate peptone in a lymphagogue action and in reducing coagulability of lymph, but does not release tissue histamine (Takaoka, 1957). These findings indicate that histamine released by these substances is derived from mast cells. The reason of occurrence of the tissue difference in the mast cells disruption by different substances was discussed.
発行日
1958-10-31
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
70巻
10号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
3803
終了ページ
3812
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/70/10/70_10_3803/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma