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ID 19010
Eprint ID
19010
フルテキストURL
Thumnail 71_107.pdf 436 KB
タイトル(別表記)
Studies on Canine Anaphylaxis Part 2. Inhibition of Histamine Release by an Antihistamine in the Canine Anaphylaxis
著者
西山 良策 岡山大学医学部薬理学教室
抄録
In the bovine serum anaphylaxis of the dog the histamine content in blood plasma was increased about 33 times and in the thoracic lymph 40 times that before reinjection. In the dogs injected with 10 mg/kg Benadryl 30 minutes prior to reinjection the maximum increase of the plasma histamine was only 4.5 times and that of lymph histamine also only 4.5 time (the average of three cases in each). In the unprotected sensitized dogs the histamine content of the liver was reduced by 54 per cent and about 6 mg of histamine was depleted of the whole liver, and 29 per cent of the skin histamine and 1 mg histamine reduced from the whole skin, under a similar shock. Histamine release from the skeletal muscle could not be recognized in any dog. In Benadrylprotected dogs 17.4 per cent of histamine was released from the liver; 2.2 mg from the whole liver; 14 per cent from the skin; and 0.3 mg from the whole skin (the average of 3 cases in each). These results support the contention that Benadryl inhibits the union of antibody (precipitin) and antigen in the dog in anaphylaxis as reported in the preceding part of this series of studies.
発行日
1959-01-31
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
71巻
1号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
107
終了ページ
114
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/71/1/71_1_107/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma