ID | 19010 |
Eprint ID | 19010
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フルテキストURL | |
タイトル(別表記) | Studies on Canine Anaphylaxis Part 2. Inhibition of Histamine Release by an Antihistamine in the Canine Anaphylaxis
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著者 |
西山 良策
岡山大学医学部薬理学教室
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抄録 | In the bovine serum anaphylaxis of the dog the histamine content in blood plasma was increased about 33 times and in the thoracic lymph 40 times that before reinjection. In the dogs injected with 10 mg/kg Benadryl 30 minutes prior to reinjection the maximum increase of the plasma histamine was only 4.5 times and that of lymph histamine also only 4.5 time (the average of three cases in each). In the unprotected sensitized dogs the histamine content of the liver was reduced by 54 per cent and about 6 mg of histamine was depleted of the whole liver, and 29 per cent of the skin histamine and 1 mg histamine reduced from the whole skin, under a similar shock. Histamine release from the skeletal muscle could not be recognized in any dog. In Benadrylprotected dogs 17.4 per cent of histamine was released from the liver; 2.2 mg from the whole liver; 14 per cent from the skin; and 0.3 mg from the whole skin (the average of 3 cases in each). These results support the contention that Benadryl inhibits the union of antibody (precipitin) and antigen in the dog in anaphylaxis as reported in the preceding part of this series of studies.
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発行日 | 1959-01-31
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出版物タイトル |
岡山医学会雑誌
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出版物タイトル(別表記) | Journal of Okayama Medical Association
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巻 | 71巻
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号 | 1号
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出版者 | 岡山医学会
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出版者(別表記) | Okayama Medical Association
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開始ページ | 107
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終了ページ | 114
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ISSN | 0030-1558
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NCID | AN00032489
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資料タイプ |
学術雑誌論文
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オフィシャル URL | https://www.jstage.jst.go.jp/article/joma1947/71/1/71_1_107/_article/-char/ja/
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関連URL | http://www.okayama-u.ac.jp/user/oma/
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言語 |
日本語
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著作権者 | 岡山医学会
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論文のバージョン | publisher
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査読 |
有り
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Eprints Journal Name | joma
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