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ID 18800
Eprint ID
18800
フルテキストURL
70_447.pdf 13.4 MB
タイトル(別表記)
Studies on the Pathogenesis of So-Called Banti's DiseasePart Ⅰ. Blood Pitcture and Metabolism of Iron and Copper in the Rabbits with Experimental Splenomegaly
著者
宮井 紋治郎 岡山大学医学部平木内科教室
抄録
The author produced splenomegaly in rabbits by the successive injections of non-physiological macromolecular polymers, and obtained the following results. 1) By the successive injections of methylcellulose, polyvinylalcohol, and ovalbumin either intravenously or intraperitoneally for the periods ranging 50-100 days, the author obtained hematologic macromolecular syndrome, marked anemia and thrombocytopenia in the rabbits. 2) Bone marrow picture revealed the inhibition of maturation in the erythroid system. 3) All the groups receiving injections demonstrated splenomegaly and an increase of the blood pressure in the portal vein. Histologic findings of the spleen were the marked proliferation of reticular cells and occasionally the picture which seems to be fibroadenia. 4) Serum iron decreased while serum copper increased on the contrary. However, the depot iron maintained the normal level. In tracing the mechanism of this experimental anemia from the fact that the depot iron did not decrease despite the marked decrease of the serum iron, the author concluded that the principal cause of this experimental anemia lies in the inhibitory action of toxic factor upon the mobilization of depot iron. The results of this experimental hypersplenism are believed to be identically the same as those of so-called Banti's disease as reported by T. Kobayashi.
発行日
1958-02-28
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
70巻
2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
447
終了ページ
469
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/70/2/70_2_447/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma