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ID 18191
Eprint ID
18191
フルテキストURL
Thumnail 80_1181.pdf 435 KB
タイトル(別表記)
The Pathway of Synthesis of DNA-thymine in Lymphocytes: An Autoradiographic Study
著者
尾曽越 文亮 岡山大学医学部第一解剖学教室
植木 絢子 岡山大学医学部第一解剖学教室
中原 裕子 岡山大学医学部第一解剖学教室
抄録
It is well established that there are two types of lymphocytes. One of these is rapidly dividing and short-lived. The thymic lymphocytes and germinal-center cells of the lymphatic tissues belong to this type. The other is produced at a slow rate and has a long life span. With respect to the incorporation of (3)H-thymidine into DNA, the former type is characterized by weak labeling autoradiographically, in contrast to intense labeling in the latter type. Experiments in mice have demonstrated that the lymphocytes of the thymus are capable of synthesizing DNA-thymine endogeneously from deoxycytidine which is circulating in a considerable amount and hence to be weakly labeled with injected (3)H-thymidine. In contrast, the majority of lymphocytes of the lymph nodes were found to be incapable of synthesizing DNA-thymine endogeneously from deoxycytidine and hence to be intensely labeled with injected (3)H-thymidine. When the pathway of synthesis of DNA-thymine endogeneously from deoxycytidine was blocked by the administration of 5-fluoro-2'-deoxycytidine, the labeling intensity of the lymphocytes of the thymus with (3)H-thymidine was greatly increased. Experiments in vitro with or without adding cold deoxycytidine to the medium provided further evidence for the utilization of deoxycytidine for the synthesis of DNA-thymine in the lymphocytes of the thymus.
発行日
1968-12-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
80巻
11-12号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
1181
終了ページ
1187
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/80/11-12/80_11-12_1181/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma