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ID 17592
Eprint ID
17592
フルテキストURL
Thumnail 88_345.pdf 1.2 MB
タイトル(別表記)
Studies on lipid metabolism in blood cells Part Ⅱ. Lipid metabolism in bone marrow cells in vitro
著者
清水 能人 岡山大学医学部第二内科
抄録
The present study was designed to investigate the lipid metabolism in bone marrow and peripheral blood cells. The author studied the in-vitro incorporation of (14)C-acetate Na into gross lipid fraction, major lipid fractions and fatty acids. Results were as follows. 1) The (14)C incorporation into the total lipid was markedly increased in bone marrow cells and whole blood cells of anemic rabbits. On the other hand, in Lanolin induced hyperlipemia, it was significantly decreased than in control, young or old. They were slightly increased but there were no differences among them. 2) After 4 hours' incubation of bone marrow or whole blood cells with (14)C-acetate in vitro, the percentage of the radioactivity recovered in diglyceride and free cholesterol was significantly increased in anemic rabbits, but in hyperlipemia decreased compared with control. 3) In hyperlipimia, the decrease of percent (14)C incorporation by bone marrow cells into fatty acid group 14:0+16:0 was supposed to be derived from the decreased activity of malonyl CoA pathway, while that into 20 Carbon and more longer chain fatty acid, formed via mitochondrial pathway, showed a significant relative increase. On the contrary, in young and old, especially in anemia, the increased activity of malonyl CoA pathway was observed in bone marrow cells but the decreased of mitochondrial pathway; the same result was obtained in peripheral whole blood cells, too.
発行日
1976-06-30
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
88巻
5-6号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
345
終了ページ
354
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/88/5-6/88_5-6_345/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
OAI-PMH Set
岡山大学
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Sort Key
4
Eprints Journal Name
joma