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ID 17532
Eprint ID
17532
フルテキストURL
Thumnail 85_35.pdf 7.71 MB
タイトル(別表記)
Study on the Intoxication by Organic Chloride Preparations for Agricultural Uses. Part Ⅰ. A simplified detection of organic chloride preparations in peripheral blood and its application to clinical use
著者
名和 英明 岡山大学医学部平木内科
抄録
According to the statistics by the Ministry of Health on toxications due to drugs for agricultural uses, we have had incidents by organic chloride compounds for many years. In future, there is also a possibility to encounter chronic intoxications by the above compounds. We have relied on solely a close observation on clinical manifestations for its diagnosis. Understandably, there has been no proper treatments established up to now. Therefore, it is a very urgent demand in our community to establish the most reliable method detecting organic chloride substance. The author have tried to devise a simplified method to detect organic chloride substance, as quick as possible in peripheral blood, using an electron capture detector. Its principle was based on gas-chromatography. Results 1) It takes approximately one hour with petroleum-ether to extract organic chlorides in peripheral blood. This is a simplified and speedy method as compared to a conventional way which needs a complicated clean-up. 2) A minimal concentration of organic chlorides to be detected is 0.008ppm for Dieldrin, 0.003ppm Aldrin, 0.02ppm p,p'-DDT and 0.003ppm γ-BHC, indicating a significantly sensitive method. 3) It is feasible to extract various organic chlorides separately by combining several columns in a gas-chromatograph, i.e., 1.5% SE-30, 10% DC-200+15% QF-1 and 1.5% OV-17. The author, thus, has been able to produce an evidence that the above method is extremely useful for diagnosing the intoxication by organic chlorides. Using this method, a part of the dynamics in the intoxicated patients has been also clearified.
発行日
1973-02-28
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
85巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
35
終了ページ
45
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/85/1-2/85_1-2_35/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/
言語
Japanese
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma