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ID 16796
Eprint ID
16796
フルテキストURL
Thumnail 91_135.pdf 280 KB
タイトル(別表記)
(103)Ru for Tumor Scanning Part II. The mechanism of ruthenium binding to tumor cells
著者
水川 帰一郎 岡山大学医学部放射線医学教室
抄録
The mechanism of (103)Ru-uptake in tumors was investigated through the incubation of rat ascites hepatoma cells (AH-130) in vitro with various concentrations of Ru-chloride containing (103)Ru-chloride as a tracer. Quantitative analysis of Ru binding to the cells indicated that ascites hepatoma cells contained high and low-affinity binding sites for Ru. When ascites hepatoma cells were incubated with Ru after incubation with a low concentration of papain, most of the Ru was not bound to the cells but was found in the medium containing solubilized glycoproteins. However Ru bound mainly to washed cells after the incubation with papain. About 65 % of the Ru bound to ascites hepatoma cells was liberated by the papain treatment, and about 45 % of the liberated Ru was precipitated by cetyltrimethylammonium bromide, indicating that Ru bound tightly to glycopeptides. These results suggest that the tumor affinity of (103)Ru is related to specific binding to glycopeptides on the tumor cell surface.
発行日
1979-02-28
出版物タイトル
岡山医学会雑誌
出版物タイトル(別表記)
Journal of Okayama Medical Association
91巻
1-2号
出版者
岡山医学会
出版者(別表記)
Okayama Medical Association
開始ページ
135
終了ページ
140
ISSN
0030-1558
NCID
AN00032489
資料タイプ
学術雑誌論文
オフィシャル URL
https://www.jstage.jst.go.jp/article/joma1947/91/1-2/91_1-2_135/_article/-char/ja/
関連URL
http://www.okayama-u.ac.jp/user/oma/index.html
言語
Japanese
著作権者
岡山医学会
論文のバージョン
publisher
査読
有り
Eprints Journal Name
joma